Update: I located a Wordpress plug-in that can be scheduled to automate your database optimization: http://wordpress.org/extend/plugins/wp-database-optimizer/ Many Wordpress customers ask about their database disk use, or their disk quota in general, because they are...
Tip #1: Host your Wordpress site yourself, not on wordpress.com. The reason for this is because a self-hosted site is completely customizable, and can include additional plug-ins and other custom code that really makes a difference. The rest of the quick tips give you the most bang for your buck right out of the gate!